Protein Modification Reagents
Sigma Aldrich Fine Chemicals Biosciences Collagenase P from Clostri
Collagenase P is an enzyme mixture prepared from the extracellular culture filtrate of a special Clostridium histolyticum strain.Collagenase P is a research biochemical not manufactured under the US good manufacturing practices (GMP) regulations.Note Collagenase P is a non-sterile preparation of the culture supernatant of Clostridium histolyticum. It is neither designed nor intended for isolation of pancreatic islets for transplantation into humans and must not be used for such purposes.
Medchemexpress LLC NH2-PEG8-acid | 100mg
NH2-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] NH2-PEG8-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]
Medchemexpress LLC Nh-bis(peg4-c2-nh-boc) | 2182601-75-6 | ≥97.0% | C30H61N3O12 | 500 MG
NH-bis(PEG4-C2-NH-Boc) is a PEG-based linker utilized in PROTAC synthesis, appearing as a colorless to light yellow liquid. This compound is intended for research use only and has not been fully validated for medical applications.
- PEG-based linker for PROTAC synthesis.
- Purity of at least 97.0% as determined by NMR.
- Stable when stored at -20°C for up to 3 years or 4°C for up to 2 years in pure form.
- Maintain stability for up to 6 months at -80°C or 1 month at -20°C when in solvent.
Medchemexpress LLC PEG4-aminooxy-MMAF | 1415246-35-3 | MFCD32201151 | 99.8% | 923.19 | C47H82N6O12 | 100 MG
PEG4-aminooxy-MMAF is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines the antitubulin payload MMAF with a non-cleavable PEG4 aminooxy linker. It is supplied as a solid for formulation and conjugation studies, with recommended storage at -20°C and documented solubility and in vivo formulation methods.
- Drug-linker conjugate for ADC research.
- Contains MMAF payload linked via a non-cleavable PEG4 aminooxy linker.
- Molecular weight 923.19; formula C47H82N6O12.
- CAS number 1415246-35-3.
- Soluble in DMSO at 100 mg/mL; in vivo formulations documented.
- Store at -20°C and protect from light; prepare fresh solutions.
![Medchemexpress LLC 4,7,10,13-tetraoxapentadecanamide, 15-azido-N-[2-(4-(triazolidin-4-yl)-2-methoxyphenoxy)ethyl] | 2639395-40-5 | 99.3% | 539.54 | C22H33N7O9 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203925.png-250.jpg)
Medchemexpress LLC 4,7,10,13-tetraoxapentadecanamide, 15-azido-N-[2-(4-(triazolidin-4-yl)-2-methoxyphenoxy)ethyl] | 2639395-40-5 | 99.3% | 539.54 | C22H33N7O9 | 25 MG
PTDA-PEG4-azide is an azide-containing PEG4 linker reagent used for antibody-drug conjugate (ADC) synthesis and bioconjugation via click chemistry. It reacts with alkyne-containing partners (CuAAC) and with strained alkynes (SPAAC); supplied for research use only.
- Contains an azide functional group for click chemistry.
- Cleavable four-unit PEG linker suitable for ADC synthesis.
- High purity (99.3% by LCMS).
- Molecular weight 539.54, formula C22H33N7O9.
- Available in small research pack sizes and stored at low temperature.
Medchemexpress LLC Nhpi-PEG4-C2-Pfp ester | 2101206-46-4 | >97.0% | 577.45 g/mol | C25H24F5NO9 | 1 G
NHPI-PEG4-C2-Pfp ester is a PEG4-based linker bearing an N-hydroxyphthalimide (NHPI) activated pentafluorophenyl (Pfp) ester used for bioconjugation and the synthesis of antibody-drug conjugates (ADCs).
- Used as a linker for antibody-drug conjugate synthesis.
- Contains a non-cleavable four-unit PEG spacer for improved solubility.
- Activated pentafluorophenyl ester enables efficient coupling to primary amines.
- Purity greater than 97.0% as confirmed by certificate of analysis.
- Molecular weight 577.45 g/mol and CAS number 2101206-46-4.
Medchemexpress LLC Mal-PEG2-NHS ester | 1433997-01-3 | MFCD24539465 | 98.6% | 354.31 g/mol | C15H18N2O8 | 250 MG
Mal-PEG2-NHS ester is a noncleavable antibody-drug conjugate (ADC) linker containing a maleimide group for thiol coupling, a two-unit polyethylene glycol (PEG2) spacer, and an N-hydroxysuccinimide (NHS) ester for amine coupling. The compound is supplied for research use and is not for human therapeutic use.
- Noncleavable ADC linker with maleimide and NHS ester functional groups.
- PEG2 spacer increases hydrophilicity and reduces aggregation.
- Facilitates conjugation between thiol-containing and amine-containing molecules.
- High purity suitable for research applications.
- Soluble in DMSO; may require ultrasonic assistance for full dissolution.
Medchemexpress LLC DSPE-PEG-Amine, MW 5000 | 95.0% | 100 MG
DSPE-PEG-Amine, MW 5000 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound is intended for research use only. PROTACs function by connecting two ligands, one for an E3 ubiquitin ligase and another for a target protein, to exploit the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Designed for selective degradation of target proteins
- Average molecular weight of 5000
- Appears as a solid, white to off-white material
eMolecules Ms-PEG4 | 139115-89-2 | MFCD22574814 | 1g
Broadpharm | Ms-PEG4 | 1g | 112541219 | BP-20704 | 98.000 | 139115-89-2 | MFCD22574814 | 228.260 | C7H16O6S
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eMolecules Hydroxy-PEG1-methylamine | 85475-01-0 | MFCD12783671 | 1g
Broadpharm | Hydroxy-PEG1-methylamine | 1g | 296213384 | BP-22918 | 98.000 | 85475-01-0 | MFCD12783671 | 119.164 | C5H13NO2
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Medchemexpress LLC 1,2,4,5-Tetrazine, 3-methyl-6-[4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)phenyl]- | 1802907-97-6 | 98.0% | C20H26N4O5 | 25 MG
Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are molecules composed of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other targets a protein of interest. They function by exploiting the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- Functions as a PEG-based PROTAC linker
- Used for the synthesis of PROTACs
- Enables selective degradation of target proteins
- Utilizes the intracellular ubiquitin-proteasome system
Medchemexpress LLC UV Cleavable Biotin-PEG2-Azide | 1192802-98-4 | 95.6% | C38H51N7O9S | 100 MG
UV Cleavable Biotin-PEG2-Azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules possessing Alkyne groups. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC)
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions